A comparative study for different period of time of administration of Cr(VI) in the drinking water and its effects in liver of Wistar rats

Methiocarb was administered orally at doses 25, 10 and 2 mg/kg of b.w. on the basis of LD50 for 1, 5 and 28 days, respectively, in rats. The results show that treatment with methiocarb increased significantly kidney TBARS levels in all groups when compared to control groups. In 1 day period; GSH levels, SOD, CAT and GSHPx activities increased. In 5 days period; GSH levels, SOD and CAT activities decreased and GSH-Px activities increased. In 28 days period; GSH levels, SOD, CAT and GSH-Px activities decreased and in contrast GSHRd activities remained unchanged in all groups. Vitamin E and taurine pretreatment may ameliorate methiocarbinduced oxidative stress by decreasing lipid peroxidation and altering antioxidant defense system in rat kidney. In histological investigations, kidney damage in the rats treated with methiocarb for 1 and 28 days was more than 5 days. The improvement of kidney damage was the most significant in the group treated with methiocarb for 1 day plus vitamin E or taurine and the least improvement in the group for 28 days plus vitamin E or taurine. These results suggested that oxidative stress may be involved in the mechanism of methiocarb-induced toxicity in rat kidney.